Wendy Smith

Director, Department of Medical Physics

Division of Medical Physics

Division Head, FCCPM

Division of Medical Physics

Associate Professor

Department of Physics and Astronomy

Associate Professor

Department of Oncology

B.Sc. Honours Physics

University of Waterloo, 1996

M.Sc. Physics

University of Waterloo, 1998

Ph.D Medical Biophysics

University of Western Ontario, 2002

Contact information

Phone

Office: (403)-521-3422

Research and teaching

Research areas

  • The effect of motion on radiation therapy, as applied to treatment of the liver, lung and breast
  • Assessing the impact of timing inaccuracy in imaging systems

Current Graduate Students

  • Sarah Weppler
  • Lingyue Sun

Biography

Academic Appointments:

  • Associate Professor, Department of Oncology, Faculty of Medicine, University of Calgary
  • Adjunct Associate Professor, Department of Physics and Astronomy, Faculty of Science, University of Calgary

Research Interests:

  • The effect of motion on radiation therapy, as applied to treatment of the liver, lung and breast
  • Assessing the impact of timing inaccuracy in imaging systems

Funding:

  • 2006-2007 New Investigator Award, Alberta Cancer Board, $50,000, Development and evaluation of an ultrasound-guided tracking and gating system for radiosurgery of liver metastases
  • 2006 New Investigator Equipment Award, University of Calgary, Development and evaluation of an ultrasound-guided tracking and gating system for radiosurgery of liver metastases

 


Publications

 (2010-2018)

 

Framework for the quantitative assessment of adaptive radiation therapy protocols
S. Weppler, H. Quon, R. Banerjee, C. Schnickel, W. Smith
J Appl Clin Med Phys 19(6): 26-34 (2018)

A Quantitative Assessment of the Consequences of Allowing Dose Heterogeneity in Prostate Radiation Therapy Planning
L. Sun, W. Smith, A. Ghose, C. Kirkby
J Appl Clin Med Phys 19(5): 580-590 (2018)

Deep inspiration breath hold level variability and deformation in locoregional breast irradiation
Conroy L, Quirk S, Watt W, Ecclestone G, Conway JL, Olivotto I, Phan T, Smith W.
Practical Radiation Oncology http://dx.doi.org/10.1016/j.prro.2017.10.011

Assessment of an Adaptive Radiation Therapy Body Contour-Based Flagging Protocol for Head and Neck Cancer Patients.
S. Weppler, H. Quon, R. Banerjee, C. Schinkel, W.L. Smith.
Red Journal (Submitted August 31, 2017)

Institutional long-term outcomes at the first Canadian center performing intraoperatively planned low-dose-rate brachytherapy alone in low- and intermediate-risk prostate cancer.
M. Peacock, K. Martell, A. Taggar, T. Meyer, W. Smith, M. Sia, S. Angyalfi, S. Husain.
Brachytherapy. 2017 Jul - Aug;16(4):822-830. doi: 10.1016/j.brachy.2017.03.011. Epub 2017 Apr 28. PMID: 28460998

Technical Note: Issues related to external marker-block placement for deep inspiration breath hold breast radiotherapy.
L. Conroy, A. Guebert, W.L. Smith.
Med. Phys. 2017 Jan:44(1):37-42.

Deep Inspiration Breath-Hold (DIBH) produces a clinically meaningful reduction in ipsilateral lung dose during loco-regional radiation therapy for some women with right-sided breast cancer. 
J. Conway, L. Conroy, L. Harper, M. Scheifele,  H. Li, W.L. Smith, T. Graham, T. Phan, I. Olivotto,
Pract. Radiat. Oncol. 2017 May-Jun; 7(3):147-53. 

Evaluation of target and cardiac position during visually monitored deep inspiration breath-hold for breast radiotherapy
L. Conroy, R. Yeung, E. Watt, S. Quirk, K. Long, A. Hudson, T. Phan, and W.L. Smith
J Appl Clin Med Phys 17(4): 25–36 (2016)

Cardiac dose reduction with deep inspiration breath hold for left-sided breast cancer radiotherapy patients with and without regional nodal irradiation
R. Yeung, L. Conroy, K. Long, D. Walrath, H. Li, W. Smith , A. Hudson, T. Phan
Radiat Oncol. Sep 22;10:200 (2015)

Adjuvant radiation therapy is feasible in epidermolysis bullosa: A case report
T. Koulis, C. Herring, W. Smith, J-P. Voroney
J Dermatol Res Ther 1:006 Sep 1 (2015)

Realistic respiratory motion margins for external beam partial breast irradiation
L. Conroy, S. Quirk, W. Smith
Med Phys Aug 21;42(9):5404-5409 (2015)

A framework for the implementation of New Radiation therapy technologies and treatment techniques in low-income countries.
D Brown, A Shulman, A Hudson, WL Smith, B Fisher, J Hollon, Y Pipman, J Van Dyk, J Einck
Europeon J Med Phys 30 791-798 July 1 (2014)

When is respiratory management necessary for partial breast intensity modulated radiotherapy: a respiratory amplitude escalation treatment planning study
S Quirk, L Conroy, and WL Smith
Radiotherapy and Oncology  112(3) 402-406 July 1 (2014)

Accounting for respiratory motion in partial breast intensity modulated radiotherapy during treatment planning: patient specific anatomical characteristics, a new metric, and population based respiratory motion
S. Quirk, L. Conroy, W. Smith
Eur J Cancer 50(11) 1872-1879 July (2014)

Measurement of time delays in gated radiotherapy for realistic respiratory motion
B. P. Chugh, S. Quirk, L. Conroy, W. L. Smith
Med Phys 41(9):091702 (2014) 

A comparison of phase, amplitude, and velocity binning for cone-beam computed tomographic projection-based motion reconstruction
N. Becker, S. Quirk, I. Kay, B. Braverman, W.L. Smith
Prac Rad Oncol 3(4) e209-e217 October (2013) 

External respiratory motion analysis and statistics for patients and volunteers
S. Quirk, N. Becker, W. Smith
J Appl Clin Med Phys 14(2), 90-101, July 1 (2013)

External respiratory motion: Shape analysis and custom realistic respiratory trace generation
S. Quirk, N. Becker, W.L. Smith
Med Phys 39(8), 4999-5003 (2012)

Clinical consequences of changing the sliding window IMRT dose rate
E. Ghasroddashti, W. Smith, S. Quirk, C. Kirkby
J Appl Clin Med Phys 13(4), 4-12 (2012)

Dosimeteric evaluation of breast radiotherapy in a dynamic phantom
G. Menon, D. Pudney, W.L. Smith,
Physics in Medicine and Biology, 56. 7405-7418 (2011) 

Using cone-beam CT projection images to estimate the average and complete trajectory of a fiducial marker moving with respiration
N. Becker, W.L. Smith, S. Quirk, I. Kay
Phys Med Biol 55(24), 7439-7452 (2010)

IMRT for the breast: a comparison of tangential planning techniques
W. Smith, G. Menon, N. Wolfe, N. Ploquin, T. Trotter, D. Pudney
Phys Med Biol 55(4), 1231-1241 (2010)

Abstracts & Presentations (2012-2019)

Rules of Thumb for the Dosimetric Effect of Head and Neck and Prostate Patients’ Body Contour Changes. Sun L, Kirkby C, Smith W.  COMP Meeting, Kelowna BC, Sept 2019

Consequences of Removing Upper Dose Constraint for Planning Target Volume in Prostate Volumetric Modulated Arc Therapy Planning
L. Sun, W. Smith, A. Ghose, C. Kirkby
Radiother Oncol. COMP-CARO-CAMRT Joint Meeting, Montreal QC, Sept 12-15, 2018

Assessing fit of rigid 3D-printed bolus for sarcoma of the knee in radiotherapy treatments
P. McGeachy, A. Yarschenko, C. Schinkel, E. Kurien, W. Smith, T. Meyer
Med Phys 45(6), e318 (2018). AAPM 60th Annual Meeting, Nashville TN, July 29 - Aug 2, 2018

Influence of Deformable Image Registration Software Implementation on Adaptive Radiation Therapy RePlan Decisions
S. Weppler, C. Schinkel, W.L. Smith
Radiother Oncol 129-1 S61 (2018). COMP-CARO-CAMRT Joint Meeting, Montreal QC, Sept 12-15, 2018

Importance of Initial Plan Parameters as a Predictor of Inter-Fractional Plan Quality Degradation
S. Weppler, H. Quon, K. Huang, C. Schinkel, W.L. Smith
Radiother Oncol 129-1 S13 (2018). COMP-CARO-CAMRT Joint Meeting, Montreal QC, Sept 12-15, 2018

Framework for the Quantitative Assessment of Clinical Adaptive Radiation Therapy Protocols (Oral Presentation).
S. Weppler, H. Quon, R. Banerjee, C. Schinkel, W.L. Smith
American Association of Physicists in Medicine 59th Annual Meeting & Exhibition, Denver, CO, July 30-August 3, 2017

Implementation of Acuros-XB from AAA for Breast: Changes in Plan Characteristics (Poster Presentation)
L. Conroy, A. Guebert, S. Weppler, M. Alghamdi, J.L. Conway, L. Harper, T. Phan, I.A. Olivotto, W.L. Smith, S. Quirk
American Association of Physicists in Medicine 59th Annual Meeting & Exhibition, Denver, CO, July 30-August 3, 2017

Optimization of Simple Flagging Metrics to Identify Adaptive Radiation Therapy Replan Candidates (Poster Presentation)
S. Weppler, H. Quon, R. Banerjee, C. Schinkel, W.L. Smith
Canadian Organization of Medical Physicists 63rd Annual Scientific Meeting, Ottawa, ON, July 12-15, 2017

Adaptive Radiation Therapy: Flagging Metrics and Future Directions (Oral Presentation)
S. Weppler, H. Quon, R. Banerjee, C. Schinkel, W.L. Smith
Tom Baker Cancer Centre Head and Neck Cancer Research Rounds, Calgary, AB, June 30th, 2017 

Assessment of a Body Contour-Based Selection Protocol to Identify Adaptive Radiation Therapy Candidates (Oral Presentation)
S. Weppler, H. Quon, R. Banerjee, C. Schinkel, W. Smith
Arnie Charbonneau Cancer Institute Howard Work-in-Progress Research Forum, Calgary, AB, April 15, 2017 

Radiation Oncology: How Physics Drives State-of-the-Art Care (Oral Presentation)
S. Weppler, C. Schinkel, W. Smith
University of Calgary Graduate Students' Associate Research in the Pub, Calgary, AB, January 17, 2017

Retrospective analysis of inter-fractional weight loss and setup uncertainties for head and neck cancer patients.
S. Weppler, W. Smith, C. Schinkel
CARO 2016 Annual Scientific Meeting, Banff September 14-16, 2016.

Does Deep Inspiration Breath Hold (DIBH) Produce a Clinically Meaningful Reduction in Ipsilateral Lung Dose During Locoregional Radiation Therapy for Women with Right-Sided Breast Cancer?
J.L. Conway, L. Conroy, L. Harper, M. Scheifele, W.L. Smith, T. Graham, T. Phan, I. Olivotto.
Radiotherapy and Oncology 120, S7. CARO Annual Scientific Meeting. Banff, September 2016.

External marker block placement on the breast or chest wall for left-sided deep inspiration breath-hold radiotherapy. 
L. Conroy, A. Guebert, W.L. Smith
Medical Physics 43(8), 4946 (2016). COMP Annual Scientific Meeting. St. John’s, NL. July 20-23, 2016.

Positional accuracy in 103Pd permanent breast seed implant (PBSI) brachytherapy at the Tom Baker Cancer Centre (TBCC).
A. Frederick,  E. Watt, P. Peacock, S. Husain, T. Meyer, M. Roumeliotis.
Canadian Organization of Medical Physicists (COMP) Annual Scientific Meeting, St. Johns NL, July 2016. Med Phys 43(8), 4933-4, 2016.

Breath hold for left-sided breast cancer: Visually monitored deep inspiration breath hold amplitude evaluated using Real-Time Position Management
L. Conroy, R. Yeung, S. Quirk, T. Phan, A. Hudson, W. Smith
Med. Phys. 42(6), 3278 (2015). Presented at AAPM Annual Meeting, Anaheim, CA July 12-16, 2015

Inter-observer and inter-modality contouring analysis for organs at risk for HDR gynecological brachytherapy
P. Sadeghi, R. Banerjee, M. Alghamdi, T. Phan, A. Tagger, W. Smith
Presented at AAPM Annual Meeting, Anaheim, CA July 12-16, 2015

Retrospective evaluation of visually monitored deep inspiration breath hold for breast cancer patient using edge detection.
L. Conroy, R. Yeung, S. Quirk, T. Phan, W. Smith
IUPESM World Congress on Medical Physics and Biomedical Engineering, Toronto, ON, Jun 8-12, 2015

In Vivo EPID Dosimetry Detects Interfraction Errors in 3D-CRT of Rectal Cancer
S Peca, D Brown, W Smith
IFMBE ProceedingsI for the IUPESM World Congress on Medical Physics and Biomedical Engineering, Toronto, ON June 8-12 (2015)

Nuclear physics night at the observatory: Uses of radioactivity in modern medicine.
W.L. Smith
October 24, 2015.

Optimal external marker block placement for respiratory management in breast radiotherapy.
L. Conroy, A. Guebert, W.L.Smith.
Radiotherapy and Oncology 120, S67. CARO Annual Meeting. Banff, AB. September 14-17, 2015.

Is there a 'Leaky Pipeline' for Women in Clinical Medical Physics in Canada?
L. Conroy, E. Watt, W. Smith
IUPESM World Congress on Medical Physics and Biomedical Engineering, Toronto, ON, June 8-12, 2015.

A dosimetric comparison of isocentric and non-isocentric coplanar SBRT VMAT plans for peripheral lung tumours
L. Conroy, H.W. Liu, H. Lau, W.L. Smith
Med Phys 41 (8), 6 (2014). Presented at COMP Annual Scientific Meeting, Banff, AB, Jul 9-12, 2014

Empirical Derivation of Site-Specific Margin Formulas
L. Conroy, S. Quirk S, W.L. Smith
Med Phys 40(6), 349 (2014). Presented at AAPM Annual Meeting, Austin, TX, Jul 20-24, 2014

Waiting to Exhale: Respiratory motion in radiotherapy
W.L. Smith
Department of Oncology Visiting Speaker Series Announcement, March 19, Calgary, Alberta (2014)

External respiratory motion analysis and statistics for patients and volunteers
S. Quirk, N. Becker, W.L. Smith
J Appl Clin Med Phys 14 (2) 4051 (2013)

Population-based dosimetric margins for respiratory motion and setup errors in partial breast irradiation
L. Conroy, S. Quirk, W.L. Smith
Radiother Oncol 108, s107 (2013)

Deliverability of partial breast IMRT with escalating respiratory motion
S. Quirk, L. Conroy, W.L. Smith
Radiother  Oncol 108, s112 (2013)

Population Based Respiratory Analysis of Partial Breast IMRT and Impact of Breast Shape and Size
S. Quirk, L Conroy, and W.L. Smith
Med Phys 40, 349 (2013)

Measurement of Time Delays in Gated Radiotherapy for Realistic Breath Motions
B. Chugh, and W.L. Smith
Med Phys 40, 231 (2013)

AAPM Medical Physics Student Meeting: Pathways to a Career in Medical Physics
G. Starkschall, and W.L. Smith
Med Phys 40, 82 (2013)

External respiratory motion: Shape analysis and custom realistic respiratory trace generation
S. Quirk, N. Becker, and W.L. Smith
Med Phys 39 , 4999 (2012)

Partial breast ITV margin from population respiratory PDF
S. Quirk and W.L. Smith
ASTRO, October 28-31, Boston, MA
Int J Rad Oncol Biol Phys 84(3), S260-S261 (2012)

A realistic respiratory trace generator and its application to respiratory management techniques
S Quirk and W.L. Smith
COMP, July 11-14, Halifax, Nova Scotia (2012)
Med Phys 39(7), 4626 (2012)

Permanent seed re-implantation using image guidance for composite dose planning
T. Meyer, M. Sia, S. Husain, W. Smith
COMP, July 11-14, Halifax, Nova Scotia (2012)

Realistic respiratory model for patients and volunteers
S. Quirk, N. Becker, W.L. Smith
CAP Congress, June 11-15, Calgary, Alberta (2012)

Development of a re-implantation procedure for dosimetric improvements in permanent implant prostate brachytherapy
T. Meyer, M. Stia, S. Husain, W. Smith
CAP Congress, June 11-15, Calgary, Alberta (2012)